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Stromal cells and matrix proteins form the structural framework of an organ, which is critical for the functioning of resident cells and for the recruitment, retention and differentiation of cells that traffic through the tissue (Shimizu and Shaw, 1991).
Fibrocytes are circulating, bone-marrow-derived progenitor cells that traffic from the bone marrow to the injured organ via the bloodstream, where they differentiate into fibroblasts and myofibroblasts, and play a pivotal role in both physiologic and aberrant fibrosis.
The underlying mechanisms of uveitis are poorly understood; however, it is interesting to speculate whether ongoing systemic rheumatic disease and increased frequency of autoreactive T cells that target specific systemic organs and tissues share commonalities with T cells that traffic to the eyes, which would render them susceptible to subsequent ocular disease.
The blood is the highway of the body, and it is likely that the cells that traffic there reflect specific defense and repair functions, as well as hints of proliferative disorders.
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In order to detect CFSE+ cells that trafficked outside of the lymphatic system, lymphocytes were also recovered from salivary glands, kidneys, lung and liver.
However, DTA-1 significantly augmented the activation of those cells that did traffic to tumor, leading to enhanced effector function (IFN-γ secretion following gp100 peptide re-stimulation) activation (CD44hiCD62Llo phenotype), and proliferation (as measured by CFSE dilution) (Figure 3C).
Selectins are vascular cell adhesion molecules (VCAMs) involved in adhesive interactions of leukocytes, platelets, and endothelial cells that mediate leukocyte trafficking and hemostasis.
However, centralized systems may respond too slowly in the emerging world of small cells that experience very transitory traffic loads.
TIMP-1-deficient mice had a decrease in perivascular accumulation of lymphocyte populations, yet an increase in the proportion of CD4+ T-cells that had trafficked into the CNS.
Because most tumor cells lack the streamlined form of the blood and immune cells that are designed for cross-body trafficking, shear forces in the smaller vessels may rip the intruders apart.
Intratumoral injection of NV1023 resulted in viral trafficking to melanoma cells that had metastasized to popliteal and inguinal lymph nodes.
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