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To discriminate between particular cancer cells and normal cells, we can design or select artificial agents that are not necessarily lethal but are aimed either at cancer-specific targets or at dispensable and even unavailable (in cancer cells) targets.
The axon of CA3 pyramidal cells targets diverse cell types, and has commissural projections, which together make it able to send information to much more of the hippocampus than granule cells.
These results indicate that γ-irradiation of human cells targets RECQ1 to associate with chromatin.
Resting Naïve CD4+ cells (targets) were labeled with CFSE and plated at 3×104/well in 96-well u-bottom plates.
For this, IFNγ-primed macrophages (effectors) were incubated with 51Cr-labeled Raji cells (targets) coated with Rituximab (10 µg/ml) at different effector to target (E∶T) ratios.
Indeed lymphoid cells (effectors) will initiate their interactions with surveyed cells (targets) by setting synapses that enable their surface receptors to interact with ligand, to concentrate activation signals, and finally to deliver effectors functions [48], [49].
Similar(42)
Stem cell implants for cancer therapy: TRAIL-expressing mesenchymal stem cells target cancer cells in situ.
Stem Cell Implants for Cancer Therapy: TRAIL-Expressing Mesenchymal Stem Cells Target Cancer Cells In Situ.
This was not the case for CD4+ T cells targeting hemagglutinin.
HLA-B∗27-restricted CD8+ T cells target three NS5B epitopes.
Ahmed, N. et al. HER2-specific T cells target primary glioblastoma stem cells and induce regression of autologous experimental tumors.
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