Exact(11)
As a carcinogen that can burn healthy tissue as well as kill cancerous cells, radiation is supposed to be closely monitored.
Surgery aims to remove the entire growth from the body; chemotherapy drugs are toxic to the cancer cells; radiation generates toxic molecules that break up the cancer cells' DNA and proteins, causing their demise.
Clonigenic assays revealed that following exposure to ionizing radiation, BxPC-3 cells with silenced ATDC were more sensitive to the effects of ionizing radiation than control cells (radiation dose for 1% survival: WT = 11.60 ± 0.06 gy; siRNA = 10.16 ± 0.70 gy).
The surgery is to remove cancerous cells; radiation "cleans up" cells the surgery can't reach, and chemotherapy can be used if the disease is more advanced or has spread to the lymph nodes.
In D283 cells, radiation increased adhesion to collagen, fibronectin, vitronectin and matrigel by 38 %, 61, 97% and 80%, respectively (Fig. 1C and 1D).
In HT29 and Panc1 cells, radiation significantly inhibited Wnt activity.
Similar(49)
Because p53 is mutated in MDA-MB-231 cells, radiation-induced glycolytic enhancement may further increase NF- κB activity.
In both HCT116 and HT29 cells, radiation-induced intracellular ROS, as seen by the increase in mean fluorescence signal intensity (in RFU).
Reduction of endothelial cells radiation-induced apottosis by basic fibroblast growth factor protects mice from gastrointestinal syndrome [ 10], and reduced small intestinal tissue damage following localized radiation exposure in PAI-1 −/− mice is associated with less endothelial cells apoptosis [ 11].
Beyond the radiation field, radiotherapy may increase the risk of lung and breast cancers through the bystander effect, in which the non-exposed cells receive signals from irradiated cells (radiation-induced genomic instability) and confer predisposition to malignancy [ 38].
Notably, in both MM.1S and 8226 cells, radiation-induced PARP cleavage at 24 h was partially blocked by 6 h of pre-incubation with ICCM and blocking of the ligand-binding IL-6 receptor α-chain abrogated the radioprotective effect of ICCM on myeloma cells.
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