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Furthermore, Red-Br-nos caused a loss of the strict correlation between number of centrioles and ploidy, which was clearly not a consequence of failed cytokinesis because a majority of treated cells perished much earlier, that is, in metaphase.
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Cells perishing in the process were contributing to building tissue framework available for subsequent remodeling.
Indeed, without continued transcription, cells cannot proceed through the cell cycle, and even nondividing cells will perish.
This releases the cell's contents for absorption by neighbouring cells, potentially preventing the death of close relatives, and thereby increasing the inclusive fitness of the cell that perished.
Some cells were perishing without succeeding in production of either proper erythrosomes or a lumen despite initiating those processes.
If, under stress, the variation engendered by the prion turns out to be deleterious, only a few cells will perish without perceptible fitness consequence to the entire colony.
In tissue engineering, vascularization of implanted scaffolds is often inadequate, and this seriously obstructs the survival of cells, which perish due to a lack of oxygen and nutrients, and insufficient removal of waste products.
The cells were perishing in the process but at the same time, they were changing the microenvironment by leaving traces of their presence in the ECM as developmental clues for other cells.
All cell lines challenged perished at 2-HG concentrations of 7.5 mM and above.
This may cause a second wave of cell death, whereby the oxidatively stressed but still viable tumor cells ultimately perish via programmed mechanisms due to the inability to restore cell function and homeostasis [ 85].
Failure in any one of these steps leads to elimination of tumor cells; 99,9% of shed cells are thought to perish during the process, while only a minor subpopulation attains metastatic capacity [ 21].
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