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A promoter fragment (−692/41) encoding the Vicia faba early nodulin VfEnod12 and containing a putative binding site for the transcription factor ENBP1, mediated reporter gene expression in root cortical cells, nodule primordia and the prefixing zone II of transgenic Vicia hirsute root nodules.
Major stages in the development of nodules include surface colonization of root hairs by the rhizobia, transport of rhizobia into inner cortex cells by infection threads, initiation of nodule primordia, differentiation and release of rhizobial bacteroids into nodule primordia cells, nodule cell differentiation and nodule growth [ 31- 33].
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Nickel potentiated the specific effects of cobalt, i.e., type II cell nodule formation.
But, in their report, the clear cell nodules were seen within the tumour itself.
It is still not clear in our case whether these clear cell nodules are lipid degeneration of pheochromocytoma, adrenocortical-cell-type nodules or lipid degeneration of periadrenal fat.
Another interesting finding in our case was the presence of three clear cell nodules in the periadrenal connective tissue.
We report such a case with additional findings of multiple clear cell nodules and brown fat in the periadrenal connective tissue.
CONCLUSIONS: In the current study of 139 FNAB specimens of thyroid Hurthle cell nodules, 14 cytologic features were examined and 6 were found to be statistically significant in identifying HCN.
A rare combination of pheochromocytoma and GIST along with multiple clear cell nodules and brown fat in the periadrenal connective tissue is being reported in a patient with NF1 syndrome.
Here, we are reporting a case of NF1 syndrome with a combination of pheochromocytoma and gastrointestinal stromal tumour with additional findings of multiple clear cell nodules and brown fat in the periadrenal connective tissue.
A germline mutation was detected in a Hürthle cell papillary carcinoma arising in a thyroid with multiple Hürthle cell nodules.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com