In tumor cells, members of the ezrin-radixin-moesin (ERM) family of cytoplasmic actin cytoskeletal linker proteins play critical roles in the regulation of metastatic potential.
In the basal domain of epithelial cells, members of the integrin family are present and allow adhesion between different layers of cells via their binding to the extracellular matrix [8].
18 In YAMC cells, members of the Ly6 superfamily are upregulated by interferon-γ, IL-22 and TNFα.
Unlike the case for T cells, members of a B-cell clone do not carry identical V(D J sequences, but differ because of SHM.
In mammalian cells, members of the Ras association family (RASSF) of tumor suppressors have been shown to bind to MST1 and modulate its activity [7].
In HSC-3 cells, members of the caspase family, cytochrome c, and I κB α were upregulated, indicating that SIN causes oncolysis by activating several apoptotic pathways.
In neuronal cells, members of the inhibitor of apoptosis protein family have previously been shown to be increased to prevent apoptosis (Frebel and Wiese, 2006).
For example, in MCF7 cells, members of the miR-520/373 family, which potently suppressed phospho-Akt levels associated with the inhibition of cell proliferation, were reported to promote breast cancer metastasis by targeting CD44 [ 44].
In the aleurone cells, members of all five groups of PDI family proteins were labeled along with calreticulin in the periphery of aleurone grains and network structure, suggesting localization of these proteins to the ER.
He attended the October 1999 wedding of another cell member, Said Bahaji.
