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This protective shield provided by local CD11c+ cells may have contributed to the evolutionary adaptation of other infectious agents to survive within granulomatous lesions.
Knowing that down regulation of CD161 expression is related to the secretion of IL-2, one can speculate that IL-2 secretion by the HBV-specific T cells may have contributed to the observed decrease in CD161 expression [39].
While it is possible that low level contamination of these purified T cell populations with TLR-bearing accessory cells may have contributed to the T cell activation by poly I C, it should be noted that these same T cell preparations were sufficiently depleted of accessory cells to remain unaffected by anti-CD3 stimulation.
Protein disulfide isomerases catalyze thiol oxidation; therefore, the decrease in PDIA1 and PDIA4 abundance in cold-adapted cells may have contributed to the recovery of PSH with rewarming.
The incidence of post-HSTC relapse correlated with the level of residual leukemia burden prior to total body irradiation (TBI), indicating the radiation-resistant population of BPL cells may have contributed to the relapse.
Although we cannot rule out that immune mechanisms other than NP-specific CD8+ T cells may have contributed to protection, our data do not support the notion that HA-specific antibodies played a dominant role.
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Gene expression microarray studies identified numerous changes in STAT3-CKO cells that may have contributed to the identified deficits in cell function.
In contrast, degradation-promoting genes— Zfp36l1 and Cnot6l showed increased expression in differentiated ES cells, which may have contributed to lower mRNA stability in the LIF− condition, but it does not explain increased mRNA stability in the RA condition.
Ectopic expression of SP-C was also observed in the bronchial epithelial cells, which may have contributed to the more rapid increase in SCGB3A2 expression in the transgenic lungs.
Both of these glial cell types may have contributed to the functional recovery, through trophic effects and the promotion of angiogenesis and axonal regeneration by immature astrocytes, and possibly through remyelination by grafted oligodendrocyte progenitor cells.
Such diminished cell elongation may have contributed to the conclusion by Naruse and colleagues [18] that suppression of FAK expression using antisense RNA inhibits cyclic stretch-induced alignment of human umbilical vein ECs.
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