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The researchers identified the primary cause of these cells' malfunction and linked it to an auto-inflammatory disorder, giant cell arteritis.
Blue petunias, they found, have genetic mutations that make two pumps inside the plants' cells malfunction.
Because proper maintenance of the apical Crb domain is important for the massive growth observed in rhabdomeres at the apical region of photoreceptor cells, malfunction of spastin results in severe defects in the formation of functional photoreceptors.
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Lesions in DNA compromise the integrity of the genome; their consequences can range from cell malfunction to malignant transformation.
Tumors employ many immunosuppressive mechanisms to subvert a protective immune response, like causing the T cell malfunction, the APC deficiencies, and the induction of regulatory T cells.
These problems include rapidly increasing contact resistance and volatilization of Cr from the oxide scales, resulting in cathode chromium poisoning and cell malfunction.
Apparent abnormalities of B-cell maturation and/or intrinsic B-cell malfunction are seen in a majority of these defects.
Evidence also suggests that immunosuppressive drugs may play an additional role in β-cell malfunction (10).
It is generally accepted that beta cell malfunction is caused by the following scenario.
Dr. Won Bae Jeon (DGIST, South Korea) used an RGD (arginine-glycine-aspartate -modified elarginine-glycine-aspartate -modifiedoarginine-glycine-aspartate -modified β cell marginine-glycine-aspartate -modified
In conclusion, CMA impairment contributes to cell malfunction in cystinosis, highlighting the need for treatments complementary to current therapies that are based on decreasing lysosomal overload.
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