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Additional micro-pillars located at the front and back of the ridges represent flow barriers which provide reduced flow velocity and a reduction in friction forces acting on the settled cells, imperative for long-term culture conditions of microfluidic hepatocyte cultures.
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Restitution of the natural organization and orientation of cells is imperative for the construction of functional tissue scaffolds.
In another recent study, we have shown that NF-κB signaling in endothelial cells is imperative for the development of atherosclerosis [14].
The ability to view single chromosome architecture in living cells is imperative to our future understanding of the functional nuclear landscape.
Thus, the identification of a mechanism that can weaken the apoptosis-resistance strategy of cancer cells is imperative to unravel novel drug targets for the design of more effective and target-selective therapeutic strategies.
Detailed studies on the intrinsic and synaptic properties of the inhibitory interneurons and their influence on the pre- as well as postsynaptic gain of the target cells are imperative for the evaluation of their contribution to normal development as well as pathological disorders.
Several therapeutic strategies are now employed to counteract the deleterious effects of cardiac hypertrophy and oxidative stress, making therefore the analysis of specific cell signaling imperative to generate novel drugs.
In the brain parenchyma, a tissue closed off from the peripheral circulation, cell-to-cell communication is imperative for the transport of essential metabolites.
In order to maintain reliable service of macro-cells, it is imperative to mitigate the destructive femto-cell to macro-cell interference.
Further, as some of the frontline strategies for treatment of cancer involve immunotherapy with ex vivo cultured or in vivo modulated dendritic cells, it becomes imperative to understand how dendritic cells interact with and are affected by the tumor microenvironment.
Moreover, it has been shown that, given low copy numbers and short life-spans of typical signalling proteins in crowded eukaryotic cells, it is imperative that binding partners in signalling cascades be colocalized in order to relay meaningful signals on reasonable time scales [8], [9].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com