Exact(4)
In damaged cells gaps in the cell membrane allow PI to enter the cell forming highly fluorescent complexes with nuclear DNA [ 7].
The nanostructure and dimension were also tailored to match the large endothelial cells gaps in tumors with enhanced permeability and retention (EPR) [ 47].
As shown in Figure 3, the high proliferation and metabolism of tumor endothelial cells resulted in the unique properties of tumor microenvironment including large endothelial cells gaps (200 1000 nm), the relative high temperature (T > 37°C), low pH (5~6), lacking of lymphatic nodes, and lymph vessels [ 4, 58].
It is known that the endothelial cells of the tumor blood vessels proliferate at a 30 40-fold 30 40-folde thigherose in norate thanues, which resulthose the larger endothelinl cells gaps (200–700 normal sometissuesven larger, up to 1.2 μm) than 7 nm in the normal tissue [ 31].
Similar(56)
Two types of junction are observed between serosa cells, gap junctions (gj) are mainly observed between adjacent cells with dense cytoplasm (Figure 6A).
Third group of bone cells, Gap 27 peptide group, was cultured with Gap 27 peptide at concentration 500 μM in DMEM-FCS.
In electrically excitable cells, gap junctions provide low resistance pathways, traditionally referred to as electrical synapses, and permit transmission of electrical signals between adjacent cells.
We carried out time-lapse imaging of these cells (GAP-EGFP electroporated) when transplanted into either the leader or rear positions of elongating WD (Fig. 6F).
In contrast to the apical junctional complex, which forms a tight seal between epithelial cells, gap junctions link the cytosol of adjacent cells to permit ions and small molecules to shuttle between cells [ 35].
In non excitable cells, gap junctions permit to share metabolic demands across groups of cells, enable the exchange of signaling molecules [ 7, 8] and the spatial buffering of potassium ions [ 9].
In NGF-treated PC12 cells, GAP-43 mRNA was found to be upregulated by < 2-fold and therefore did not meet the exclusion criteria applied in the current work.
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