Sentence examples for cells functionalities from inspiring English sources

Taking advantage of a previously described strategy to control TALEN targeting based on the exclusion capacities of non-conventional RVDs, we have developed highly efficient and specific nucleases targeting a key T cell immune checkpoint, PD-1, to improve engineered CAR T cells' functionalities.

In patients with Wiskott Aldrich syndrome (WAS), thrombocyte and immune cell (but also all other mature blood cells) functionalities are impaired due to a defect in a haematopoietic protein (WASp) responsible for linking receptor signalling to organization of the actin cytoskeleton (Notarangelo et al, 2008).

Sertoli cells were found to be more severely affected which in turn can hamper germ cells functionality.

High lactate concentration in tumor microenvironment might affect immune cells functionality.

In cancer, such effects of lactate could favor the local immune tolerance of the tumor by suppressing immune cells functionality.

CD4+ T cells functionality was evaluated by anti-OVA IgG titration (Figure 6B).

For example, stem cells functionality decreases with age; thus, older patients may not present the perfect population as donors [ 72].

Moreover, the recovered cells resumed the proliferation as well as a normal degree of cell division (Fig. S6), also suggesting that basic cell functionalities such as enzymatic or mitochondrial function were not affected.

Its effective operation achieved via fine tuning the connectivity to native cell functionalities emphasizes the potential of this concept to expand microbial substrate and product scopes.

Thus, it is expectable different cell functionalities will use different strategies of gene and protein expression and degradation.

Our findings demonstrate the potential of the proposed approach for the discovery of new cell functionalities with complex dependences on more than one variable.