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But the process of the cells' demise is still largely a black box.
Süel thinks overcrowding within a biofilm leads to the cells' demise.
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Development of more potent and selective small-molecule drugs that activate ER Golgi mediated cell demise is also needed.
For decades, research has sought to unravel the molecular events mediating sensory cell demise, emphasizing the roles of reactive oxygen species and their potentials as therapeutic targets.
Above changes were related to altered cell demise (apoptosis and necroptosis), as shown by upregulated expression of cleaved caspase 9, cleaved caspase 3 and RIP1/RIP3/MLKL cascade.
Expanding our knowledge of the molecular "crosstalks" that regulate tumor cell demise is crucial in guiding the successful design of future anti-cancer therapeutics.
Tumor cell demise is an important event in the elimination of abnormal malignant cells and provides an important mechanism of natural tumor suppression.
Taken together, our data provide evidence that metergoline elicited cell death process in C. krusei through elevation of the intracellular ROS level and perturbation of mitochondrial homeostasis, followed by damage of nucleus and eventual cell demise.
Understanding the intricate crosstalk between autophagy and necrosis is essential, as this process, on the one hand, is required for necrosis while, on the other, can act as a pro-survival mechanism to inhibit cell demise.
To conclude, we show that both early Ca2+ influx and mitochondrial decay are conserved mechanisms of pyroptotic cell demise that are mediated by GSDMD and precede plasma membrane rupture following caspase-11 activation.
The team's goal is to engineer an optimized version of these proteins and use them to slow down metabolic activity in injured cells — the biological equivalent of hitting the pause button on cellular processes, including damage-causing inflammation, infection and, ultimately, cell demise.
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