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We believe that this new reporter virus system will be of great help to study in depth how HIV-1 interacts with its host in a primary cells context.
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Subsequently, we performed class I & IIa HDACs whole cell enzyme assay to evaluate inhibitory activity in whole cell context.
Therefore, transcriptional activation by enhancer-targeting dLbCpf1-p300core proteins could be achieved in a cell context dependent manner.
Sherwood, NT, Lesser, SS, and Lo, DC. "Neurotrophin regulation of ionic currents and cell size depends on cell context". Proc Natl Acad Sci U S A 94, no.
It is not known if all such regulatory effects are obligatory, or if some may vary depending on the cell context in which the receptors are expressed.
Cell type-specific and spatial expression of ligands and/or receptors can regulate Notch signaling to a certain cell context or population (Radtke et al., 2010).
We propose FKBP51 may represent an element, within melanoma cell context, that allows the tumour to take advantage of tumour-promoting activities of the TGF-β.
This cell context independence suggests a rather direct regulation of Fgf8 gene expression by β-catenin.
Different levels of GSK3β inhibition are proposed to exert different responses depending on cell context or cell type [14], [56].
Thus, the cell context appears determinant for the ability of USP19 to regulate cell proliferation and p27Kip1 levels.
Its role in altering cell differentiation programmes has received limited attention, and is likely to be dependent on cell context.
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