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The cerebellum and specifically cerebellar Purkinje cells are implicated in tottering mouse attacks.
Surgery-induced angiogenesis of dormant avascular micrometastases and surgery-induced activity of single malignant cells are implicated.
Mast cells are implicated in EIB, but the characteristics, regulation, and function of mast cells in patients with EIB are poorly understood.
Particular emphasis is also placed on clinically used drugs for other indications that stabilise mast cells and how this additional action may be harnessed for their clinical use in disease processes where mast cells are implicated.
On the basis of recent findings, it becomes increasingly evident that resident stromal cells (fibroblasts, endothelial cells) are implicated in the metastatic process, including proliferation, matrix degradation, or migration of melanoma cells through cell cell cross-talk by soluble factors (proteases, cytokines, growth factors) or by direct contact.
Excess fat cells are implicated in the cause of serious health conditions -- cancer (breast, colon and pancreatic), dementia, heart disease, high blood pressure, diabetes (Type II), osteoarthritis, metabolic syndrome and sleep apnea to name a few.
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Promoting NF-κB-mediated gene transcription in CD4 + T cells is implicated in its immunomodulatory activity.
Increased iNOS expression in glial cells is implicated in the etiology of CNS diseases by causing inflammation and cytotoxicity [20, 21].
Additionally, the intensity of PD-L1 expression by tumor cells is implicated to be a potential predictor of the efficacy of PD-1 pathway blockade (Topalian et al., 2012).
Surprisingly, AQP1 and AQP2 proteins identified in urine exosomes via secretion through renal ductal cells were implicated in pathophysiological processes in urinary epithelial cells [13].
Hyperglycaemic impairment of nitric oxide (NO) production by endothelial cells is implicated in the effect of diabetes to increase cardiovascular disease risk.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com