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These reporter probes are transported into cells, and trapped as a result of enzymatic phosphorylation by HSV1-TK.
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The net accumulation of radiolabelled choline (choline uptake) is a function of both choline transport into cells and trapping through phosphorylation (by choline kinase).
The force is applied through an Arg-Gly-Asp-coated bead adhering on the cell and trapped in optical tweezers controlled by a feedback loop.
They were tightly bound, and often internalized or transported into the cell and trapped inside by metabolic transformation, while unbound ligand was cleared.
The most widely used PET tracer is fluorine-18 fluorodeoxyglucose ([F]FDG), which is an analogue of glucose that is transported into cells, phosphorylated and trapped within cancer cells more avidly than by normal cells.
In addition, we demonstrated that 99mTc-SD32 wasubjecteded to bioreduction in hypoxic cells and was trapped as the corresponding carboxylate anion.
The nanoparticles entered the cells and were trapped inside the cytoplasm but did not appear in the cell nucleus (Fig. 3b).
The tissue-to-blood efflux constant, k2, was zero in both cortex and tumor, suggesting that BSO entered cells and was trapped once it crossed the blood-brain barrier.
H2DCFDA can easily diffuse into cells and is trapped after cleavage of H2DCFDA to H2DCF by intracellular esterases.
Normal tissues utilize glucose for energy and FDG is a glucose analog that is taken up by cells and then trapped intracellularly in this pathway.
If all cancer emboli contained the same number of cells and were trapped in the lung at the same time, then there might be a crop of metastases of the same size.
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CEO of Professional Science Editing for Scientists @ prosciediting.com