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The resultant hyperglycemia raises the plasma osmolality, which leads to movement of potassium out of the cell, worsening hyperkalemia.
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In contrast, the stability of rDNA in the mother cell worsens with age.
However, in the EAE model in which B cells do not play an encepalithogenic role, B-cell depletion decreases Treg and regulatory B-cells, worsening the disease course [ 17].
Under diabetic condition, chronic hyperglycaemia may induce large amounts of ROS that are responsible for the progressive dysfunction of β cells, worsening insulin resistance and further promoting relative insulin deficiency ROS [ 17].
Scattering cancer cells worsens the disease and decreases a patient's chances of long-term survival.
In NOD mice, the deletion of Treg cells worsens autoimmune activity [ 52].
In NOD mice, the deletion of T-reg cells worsens autoimmune activity [ 48].
PLA2G5 overexpression in bone marrow cells worsens atherosclerosis, whereas its deficiency decreases modestly the atherosclerosis [ 9].
Depletion of macrophages and dendritic cells worsened the histopathology with crypt destruction and epithelial disruption in experimental colitis [ 41].
Indeed, depletion of NK cells worsened colitis in a CD4+ T cell transfer model in mice, demonstrating an immunoregulatory role for NK cells [ 69].
Additionally, it was shown that bone marrow transplantation of PPARγ−/− cells worsened the outcome of atherosclerosis, strongly suggesting a role for PPARγ in macrophages involved in lesion formation [113].
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