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Using direct RNA FISH, it is also clear that the level of expression of DXZ4 differs from cell to cell within the same cell line; with some cells showing little to no expression whereas others may show DXZ4 localized transcript patterns comparable in size to that of XIST RNA.
Indeed, an individual normal cell, within the same biochemical milieu, will divide, differentiate or undergo apoptosis simply because of its external shape (Huang and Ingber, 1999).
More recently, Nebbia et al. found that in HBV-infected individuals receiving anti-viral treatment, Tim-3 expression was significantly increased on the exhausted HBV-specific CD8+ T cells compared with the overall CD8+ T cell within the same patient.
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Most ion channel densities vary from location to location in a given cell, not to mention from cell to cell even within the same class of cell, let alone from report to report in the experimental literature.
These results show that MIND is a promising analytical tool to distinguish different cells types and identify cell heterogeneity within the same cell population by quantifying and categorizing changes in the morphology of nuclei in response to micropatterned substrates.
But it can also vary from cell to cell, even within the same individual.
Beta-cells within the same islet were manually counted in a blind setup.
And he points to recent studies showing that different cells within the same tumor can have different genetic mutations.
Our work establishes the tools and a new developmental model to study the molecular mechanisms underlying the switch between proliferative and functional beta-cells within the same islet.
FITC-labeled apoptotic cells within the same microscopic field were viewed and photographed by phase contrast (PC) or by fluorescence emitted at 518 nm (FITC filter).
Different types of cell processes occurred in different areas of the same cell and on different cells within the same composite.
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CEO of Professional Science Editing for Scientists @ prosciediting.com