Poor NER in male germ cells warranted studies of the fate of DNA lesions induced in male germ cells, and whether residing DNA lesions could induce de novo mutations.
In vivo (or in artificial systems mimicking the in vivo conditions), the oxidized primary donor is reduced by an external electron donor, and the excited electron is funnelled in the direction of the metabolic pathways of the cells, warranting the conditions for repeated turnover of the RCs.
Additionally, whether PSI is degraded in vivo, or whether it could be transported into cancer cells warrant investigation.
Psickle and the deoxygenation-activated Ca2+-permeable cation conductance reported here may arise from oxidative, proteolytic, or other modifications of proteins present in AA red cells, warranting consideration of modified native AA cell conductances as possible contributors to Psickle.
Although not protective after subsiding in one macaque, chemo-vaccination-induced T cells warrant more comprehensive analysis during peak responses for their ability to prevent or to control infections after additional exposures.
Mechanisms of mtDNA maintenance in carcinoma cells warrant further investigation.
Because translocations and deletions occurred during late passages, the presence of rare tumorigenic variants in A0 cells warrants our concern.
Whether or not mifepristone-induced cytostasis, and alterations in cell shape, cytoskeletal structure, and adhesion capacity affect the migratory and invasive properties of cancer cells, warrant further investigations.
It appears that LKB1 regulates several important cellular processes in human breast cancer cells, warranting further investigation into how its expression is controlled.
In addition, most of the current studies focus on the cytotoxicity of MJ on cancer cells, while the effects of sub-cytotoxic MJ on the invasion, metastasis and angiogenesis of cancer cells warrant further investigation.
