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Consistent with expectation [28], [46], [47], dopamine (100 µM) applied to wild-type retinas produced a shift in the weight of the ganglion cell tuning curves toward higher spatial frequencies (Fig. 5A, p<0.0011, KS test; data are also presented as average tuning curves in Supp. Info. Fig. S2a).
As this updated part is fairly long, please refer to the subsection headed "Equally optimal non-lattice solutions for grid cell tuning" in the revised manuscript.
In fact, this logic is revealed in the second part of the Results ("Prior experience and CA3 NMDARs accelerate CA1 place cell tuning and coordination in novel environments").
We will consider four grid modules with module periods λ i, Gaussian standard deviations σ i of the bump of the grid cell tuning curve, and ratios λ i / σ i = 9.1.
The authors demonstrate the dependence of the temporal sequence and place cell tuning changes on CA3 NMDARs and presumably their activity but not synaptic plasticity itself as stated in the Abstract and in the manuscript.
(10) f θ = c + (1 − c ) exp [ ν (cos − 1 ) ], where c = 0.2 and ν = 0.8 are parameters determining the minimum value and the width of the cell tuning curve.
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Specifically, the weight of the ganglion cells' tuning curves shifted from low spatial frequencies toward high.
Our studies also showed a pattern of intermixing between the color and disparity pathways of V2, including the existence of single cells tuned for both color and disparity.
These intermingled subnetworks, described in vitro, may relate to the intermingled ensembles of cells tuned to different orientations, described in vivo.
The system can provide the responses of complex cells tuned to five different disparities and a disparity map obtained by comparing these energy outputs.
The model simulates responses of a simple cell as determined by excitation of LGN cells tuned to the spatial frequency of the test grating (Figure 3).
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