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This would imply that each cell transits through different configurations.
When the cell division stops in the p-RD state, the cell transits to the RD state, in which the cell remains but the virtual clock stops permanently.
Future delineation of these molecular mechanisms should substantially advance our understanding of how the cell transits from the state of checkpoint activation to recovery.
In addition to alteration of nucleosome positioning as a cell transits through mitotic division [ 8], there are a number of posttranslational histone modifications that are either maintained or changed, and which may impact gene expression after mitotic exit [ 9 12].
DOI: http://dx.doi.org/10.7554/eLife.08924.014 Possibly, absolute concentration of Yan is unimportant when a cell transits to a different state, but the switch to a constant basal Yan level is robustly maintained regardless of starting concentration.
When the cell transits from state 1 to state n after many steps, the cell will stay at state n in the suitable culture condition since endogenously expressed pluripotency genes can reinforce their expression [ 1].
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NPS involves measuring the modulated current pulse caused by a cell transiting a microfluidic channel that has been segmented by a series of inserted nodes.
The synchronization phase makes the automaton of each cell transiting from the inactive state to the initial state.
Electronic microscopy revealed a decrease of astrocytic end-foot swelling, which could improve red blood cell transit time.
Parameters like cell transit time through constrictions, transit or passage time, entrance time during squeezing and transit velocity were used for cell deformation measurements.
Considering capillaries architecture as a central role for oxygen delivery to the cell [18], heterogeneity of red blood cell transit time into capillaries could lead to hypoxia in the injured brain, despite normal CBF.
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