Indeed, Finn et al (2007) recently reported a highly significant relationship between breast cancer cell line subtype based on gene expression of cytokeratins and sensitivity to src kinase inhibition, suggesting that the 'triple negative' breast cancers were most likely to benefit from Src inhibition.
We used similar criteria to assign breast cancer cell lines to three clinical subtypes based on information provided in Neve et al (2006).
148 Liposarcoma is divided into several subtypes based on the extent of cell differentiation and cell morphology: well-differentiated, dedifferentiated, myxoid, round cell, and pleomorphic liposarcomas.
Acute myeloid leukemia (AML) is divided into 8 subtypes based on abnormal cell types and degree of maturity [ 7].
More recent studies using single-cell profiling techniques have documented astrocyte subtypes based on gene expression profiles (Rusnakova et al. 2013; Stahlberg et al. 2011), with molecular differences including glutamate and GABA receptor composition (Hoft et al. 2014) and the expression of gap junction isoforms (connexins) (Griemsmann et al. 2014).
Here, we established a pancreatic tumor organoid library encompassing 39 patient-derived PDACs and identified 3 functional subtypes based on their stem cell niche factor dependencies on Wnt and R-spondin.
When NK cells were subtyped based on CD56 expression levels, the median frequencies of CD56bright NK cells were significantly greater in SF than PB in both patient groups (P ≤0.001).
Breast cancer cell lines have been classified into three broad subtypes based on the expression of the intrinsic genes: luminal, basal A or basal B [ 29, 30].
Recently, our lab identified another 2 HCC subtypes based on their expression of a hepatic stem cell marker, epithelial cell adhesion molecule (EpCAM) and EpCAM-coexpressed genes[ 91].
The most common form of malignant renal neoplasms is renal cell carcinoma (RCC), which is classified into several different subtypes based on the histomorphological features.
