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Nevertheless, some colonial organisms (e.g., Dictyostelium discoideum, supergroup Amoebozoa) exhibit high levels of cell specialization that border on multicellularity.
Discussion of the causes of cancers necessarily involves an examination of the molecular machinery in cells that guides the basic processes of proliferation (increase in cell number by cell division), differentiation (cell specialization into different tissue types), and apoptosis (programmed cell death).
At earlier stages, they affect cell lineage decisions and at later stages, they inhibit cell specialization.
Nanney (1960) suggested that epigenetic inheritance played a role in cell specialization in unicellular populations (colonies), which conferred economic benefits to individual cells and enabled populations to survive environmental traumas due to their heterogeneity, prior to the emergence of true multi-cellularity.
Such potential reinforcement of lineages only strengthens the conclusion that differentiation of ecological roles is likely to be easier at early stages of evolution, before there are high levels of cell specialization.
If anything, a trend towards greater lamination is found in type 1 brains, instead of in type 2. It must be considered also that those species that present significant evolutionary changes in both traits are also those that present the higher degree of lamination and cell specialization in their groups.
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In several tubules signals of acute tubular necrosis were observed, for instance, an apparent loss of tubular epithelial cells specialization (brush border) and presence of necrotic debris and necrotic epithelial cells in the lumen).
In contrast, effector genes responsible for cell differentiation and specialization might not require these rich and complex regulatory inputs, and would not be methylated.
Tissue-specific analysis supported by LMD has the potential to substantially improve our understanding of complex processes including cell differentiation and specialization associated with stem growth, wood development and the inducible formation and activation of defense-related structures such as resin ducts.
The former strategy allows Clade 1 cyanobacteria to be highly flexible in terms of not only developmental capacities (e.g. specialization via cell differentiation: akinetes, heterocysts, diazocytes), but also physiological performance (e.g. nitrogen fixation, symbiosis) and a wide habitat occupancy among prokaryotes.
One can distinguish between different subsets of DCs based on functional and phenotypic variation [25] and the presence of highly degradative lysosomes in MDDCs points to a cell biological specialization that separates this subset from other DCs.
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