We have studied how lineage commitment is executed during development by focusing on how ES cell-derived FLK1+ mesodermal cells segregate into the blood lineage and suppress alternative cardiac and paraxial lineage programmes.
Neural stem cells segregate age-related damage by establishing a diffusion barrier during cell division.
Although cell-cell adhesion seems likely to play a crucial role in this process, how glomerular epithelial cells segregate from the other parts of the nephron is unknown.
van Deursen, along with a then-graduate student, Darren Baker, engineered mice to produce less BubR1, a protein that helps cells segregate their chromosomes when they divide.
During mitosis and meiosis cells segregate their replicated genomes to daughter nuclei [1].
Interestingly, Rx−/− and wild type cells segregate before the morphogenesis of these two tissues begins.
Drosophila adult muscle precursor cells segregate as sister cells from embryonic founders and give rise to all adult muscles in the pupa [6], [7].
Based on genome-wide mRNA expression and cluster analysis, we demonstrate that bones and cultured adult bone-derived cells segregate according to site of derivation.
When co-cultured with liver cells (BNL.CL2), the B16-GFP melanoma cells segregate presumably due to different cellular adhesion properties, forming islands of GFP+ cells expressing melanin distributed among the BNL.CL2 liver cells (Figure 1A).
While in the mature rodent the lateral dendrites of mitral and tufted cells segregate in the deep and superficial substrata of the EPL, respectively, little is known about the time course or mechanisms underlying their development [4], [5].
