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hSM-like cell samples were compared to hASCs and to the positive control, human coronary artery-smooth muscle cells (hCA-SMCs) through gene transcription profiling.
Levels of SNAT subtype mRNA expression in cytotrophoblast cell samples were compared statistically using a non-parametric paired test, with a p value of <0.05 considered significant.
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The results showed a 125-fold lower FOXP3 expression (p = 0.0001), 52-fold lower CTLA4 expression (p = 0.003), and almost undetectable RORyt expression (p = 0.005) when plasma cells samples were compared to total BM (Fig. 1).
To this end, we used various different types of comparisons regarding the cancerous/normal state, provided that in each experiment a colon cell sample was compared with a blood cell sample.
All possible pairs of tumor and cell line samples were compared using the Pearson's correlation coefficient as the metric of similarity.
The expressions of miRNAs in the pancreatic cancer cell and tissue samples were compared by using Student's t-test.
The DNA synthesis values of normal and metaplastic cell cultures in paired samples were compared using the exact Wilcoxon two-sample test.
In this design, treated Hepa1c1c7 cell or hepatic tissue samples were compared to the corresponding time-matched vehicle control with two independent labelings (dye swaps; Additional file 8).
To compare drug responses on a wider scale, we performed two separate clustering analyses in which CML BC (cell line and primary) samples were compared with primary samples from different types of leukemia.
Finally, for the AfCS mouse B cell dataset, treated versus untreated samples were compared in triplicate and analyzed at the last time point (4 hours).
The cell counts of drug-treated and control samples were compared to calculate the percentage of viable cells that remained after drug treatment.
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