Exact(2)
MMTT variables included: insulin sensitivity (Si); beta cell responsivity (Φtot); and disposition index (DItot = Si* Φtot) following 470 kCal meal.
There was, however, a decrease in NTGMD with a lag of 1 day, suggesting the possibility of an impairment of smooth muscle cell responsivity to nitroglycerin with a slight delay.
Similar(58)
Two SNPs (rs6923761 and rs3765467) were nominally associated with altered β-cell responsivity in response to GLP-1 infusion.
β-Cell function was evaluated by determining the disposition index (DI), which represents the insulin secretory response in relationship to IS, calculated as the product of the β-cell responsivity index (Φo) and Si (15).
28 An index of total beta-cell responsivity to glucose (ϕtotal) is derived subsequently.
β-Cell responsivity (ΦTotal) was measured using a C-peptide minimal model.
From Φd and Φs, one can also calculate a single overall β-cell responsivity index.
This was also reflected in a lack of effect on β-cell responsivity and insulin action.
Insulin action and β-cell responsivity indices were estimated using the minimal model.
β-Cell responsivity decreased by 20% in progressors, whereas it remained stable in nonprogressors.
The disposition indices (DId, DIs, and DIclamp) were then calculated by multiplying β-cell responsivity indices by IS.
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