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However, it has now been shown that loss of carcinoma cell responsiveness to TGF-β stimulation can also promote metastasis.
Similarly, altered associations in CFS provided indirect evidence of diminished NK cell responsiveness to IL-12 and LT-α stimulus.
We have investigated monocyte and T cell responsiveness to silk based biomaterials of different physico-chemical characteristics.
Further in vitro as well as pre-clinical studies are needed to better correlate the use of different stimuli to the cell responsiveness.
It was hypothesised that NM physico-chemical characteristics would influence cell responsiveness by altering intracellular Ca2+ concentration [Ca2+]i and reactive oxygen species production.
The latter cells may dramatically affect the outcome of experiments carried on to evaluate NK cell responsiveness to TLR agonists such as LPS.
Furthermore, fiber alignment in collagen scaffolds enhanced the gene expression of aggrecan, indicating cell responsiveness to anisotropy that also better replicates the natural environment of cartilage.
We next investigated whether higher MMP7 expression correlates with loss of cell responsiveness to the drug.
Finally, N cell responsiveness was modified after changes in chromatin packaging.
Cell responsiveness to a therapeutic intervention may also be altered by a context of long-term mutant homozygosity.
These results show that cell responsiveness to signalling pathways, in particular to the N-pathway, fluctuates along the cell's life.
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