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These changes are related to the rate of cellular turnover because there is a slow cell replacement at birth while an increase takes place at weaning together with a decrease of enterocyte lifespan [ 11].
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With further investigation of additional key events or factors necessary for this fate switch, this cellular system could provide an important tool for the design of new strategies aimed at cell replacement.
The lack of observable gross deficiencies in T1D SC-β cells combined with their functional phenotype indicates the potential utility of these autologous cells in cell replacement therapy for diabetes for at least a proportion of the T1D population.
The study, "β Cell Replacement after Gene Editing of a Neonatal Diabetes-Causing Mutation at the Insulin Locus," was published Dec. 11 in Stem Cell Reports.
She has continued her research program at Rockefeller, where her work focuses on the potential of cell replacement therapy to inform the development of treatments for Parkinson's disease.
Certainly, I love the idea of cell replacement.
Intestinal stem cell replacement follows a pattern of neutral drift.
Many companies pursuing cloning and cell replacement therapies, not all from embryonic stem cells, have gone out of business.
Neural stem cell transplantation in central nervous system disorders: from cell replacement to neuroprotection.
Lamba D, Karl M, Reh T. Neural regeneration and cell replacement: a view from the eye.
Arenas, E. Towards stem cell replacement therapies for Parkinson's disease.
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