Sentence examples for cell redirection from inspiring English sources

One of these targets FCGR3A (CD16a) for NK cell redirection, while the other 26 bispecific antibodies target CD3E on T cells to redirect the cytotoxic T cells (CTLs) to kill and lyse cancer cells.

Twenty-seven clinical stage bispecific antibodies are immune cell redirection bispecific antibodies.

Another area that has not yet been fully investigated with respect to T cell redirection is the role of Fc functionality.

Typically in the case of bispecific T cell redirection antibodies, the affinity for the cancer cell surface target is much higher (i.e., 10-fold or more) than the affinity for the CD3E chain on T cells (Zhukovsky et al., 2016).

The most significant use of bispecific antibodies, however, is for T cell redirection, in which one combining site is directed toward a cell surface target on a cancer cell and the other combining site binds CD3E on T cells to redirect those cells to the targeted cancer cell (see below).

Thus, derivation of proficient iPS cells from elderly T2D patients is feasible, expanding the spectrum of disease entities amenable to somatic cell fate redirection.

In addition to the inherently high expression of selective stemness genes c-MYC and KLF4 which may facilitate cell fate redirection, keratinocytes were amenable here to culture in xeno-free systems, and responsive to feeder-free reprogramming, rendering HK cells a robust source for iPS derivation from elderly T2D patients.

The induced AE protein in embryos redirects erythroid progenitor cells to develop into granulocytic cells, strongly resembling the cell fate redirections observed in AE-associated AML patients.

Root development and growth, however, depends on both on an apical-basal auxin gradient with its greatest concentration in the region of the QC (generated by polar transport through protophloem cells) and redirection of that auxin flow laterally in the root cap where it subsequently flows back toward the shoot (through lateral root cap and epidermal cells) [ 58].

However (third), the cells undergo a redirection of cell fate when a histone methyltransferase is overexpressed, indicating that they can readapt.

Bioinformatic analysis of transcriptome data identified pathways involved in epithelial-to-mesenchymal transition and cytoskeletal remodeling as most significantly affected networks in response to reprogramming of HK cells, in line with genuine redirection of cell fate (data not shown).