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Kato, R. et al. Parametric analysis of colony morphology of non-labelled live human pluripotent stem cells for cell quality control.
By using an engineered green fluorescent protein as reporter we have examined how the cell quality control distributes such active but misfolded protein species between the soluble and insoluble cell fractions and how aggregation determinants act in cells deficient in quality control functions.
Therefore we can acquire a homogeneous population of regenerative cells with uniform characteristics, which is crucial for cell quality control in further clinical application.
Additional roles in stress response and/or cell quality control were also recently described (Schuster and Bertram 2013).
Taken together, these new findings highlight the importance of competitive interactions in cell quality control in mammals.
The ubiquitin proteasome pathway is responsible for cell quality control by eliminating defective proteins from the cytosol and endoplasmic reticulum.
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The results showed above highlight the consequences of nonfunctional cell-quality control within developing tissues.
The guidance covers a wide range of processes involved in stem cell banking, including procurement of cell lines, cell banking procedures and documentation, cell banking quality control, and the process of releasing cell banks.
Srour, N. et al. A plasma cell differentiation quality control ablates B cell clones with biallelic Ig rearrangements and truncated Ig production.
On the other hand, cryopreservation of cells is preferred for cell analysis, quality control, and sterility testing.
These pathways and mechanisms, roughly half a dozen in all, affect metabolism, growth, response to stress, stem cell vigor, inflammation, and proteostasis the cell's quality control system for proteins.
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