In the lateral direction from the organ of Corti, the epithelium comprises spiral prominence cells and marginal cells of the stria vascularis.
However, the idea that neuronal precursors may originate locally in the cortex or even from leptomeningeal cells is gaining prominence (Nakagomi et al., 2012).
Consequently, therapeutic targeting of B cells is gaining prominence in our clinical armamentarium for an ever expanding array of autoimmune and neoplastic disorders.
Based on studies in adult mice, pendrin is expressed in the cochlea in outer sulcus and spiral prominence epithelial cells and in spindle cells of stria vascularis [15], [16].
Storage was evident in the spiral ligament (Fig. 8E) (Type II, III, and IV fibrocytes, and epithelial cells of the spiral prominence), the spiral limbus (stellate fibrocytes and interdental cells), Reissner's membrane (both epithelial and mesothelial cells), and mesothelial cells lining the bony capsule.
Indeed, the prominence of cell wall invertase induction has led to a proposal that it be classified as a pathogenesis-related protein [ 45], which is a large class of defense proteins that become highly expressed following biotic defense activation [ 51].
HIV affects the determination of the Th1 vs Th2 profile, as both increased viral load and decreased CD4+ cell count lead to prominence of IL4 over IFNγ (Altfeld et al., 2000).
An ultrastructural study of copper-challenged NR liver revealed the prominence of Kupffer cells, the latter phagocytic cell comprise about 2% of the liver cell population and yet are estimated to contain approximately 26% of the liver's lysosomes which may in part account for the increased levels of cathepsin D observed.
Prominent categories displaying expression increases in all three prominences included cell adhesion, cell migration, and cell morphogenesis.
