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These patients showed no differences in pulmonary function tests and BAL cell profile (data not shown).
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(A ) Relative expression levels of key TFs in different subsets of MECs are indicated ('+++', '++', '+', '±', '−' indicate highest to low to no expression, based on [ Figure 1I ] and our single cell profiling data for sorted MECs [MPAvB and ZL, unpublished data]).
Reduced Grb7 levels did not have a major impact on the cell cycle profile (data not shown).
Complete cell cycle profile data is given in Additional file 4: Table S4.
Wt and mt cell lines proliferated at similar rates, with similar cell cycle profiles (data not shown), and identical cell numbers were analyzed for each cell type.
We curated cell line profiling data consisting of 59 cell lines that were characterized using various genetic and proteomic profiling methods.
Beyond algorithmic differences, the conceptual limitation shared by these models was the unfeasibility of extrapolating the data to novel compounds and cell lines simultaneously, as the cell line profiling data and chemical information were separately used as predictive features and were not integrated into a single machine learning model.
Examination of patterns of sensitivity across a large collection of cell lines revealed an opportunity to use cancer cell line profiling data as another unbiased approach to identifying small-molecule mechanisms of action.
Using cancer cell line profiling data sets, we constructed a functional classification across 107 cancer cell models, based on their common and unique target addiction signatures.
Encoding cell lines with cell line kernels led, in some cases, to models with comparable predictive power to those trained explicitly on the cell line profiling data.
Between 1 h and 24 h of E2 treatment we saw intermediate cell cycle profiles (data not shown).
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