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The Purkinje cell pause response was also shown to be resistant to pharmacological blockade of inhibitory interneurons.
Such an increase is likely to result from delayed Golgi cell firing following the direct afferent inhibition, and is not expected to occur if the Golgi cell pause was produced by a decrease in incoming excitation.
The Purkinje cell pause modulates the activity of the vestibular nuclei, resulting in an eye movement waveform (magenta trace, bottom of Fig. 1D) that is larger and more irregular than an inferior olive signal itself would produce (magenta trace at bottom of Fig. 1C).
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Jirenhed, D. A. & Hesslow, G. Are Purkinje Cell Pauses Drivers of Classically Conditioned Blink Responses?
Based on these findings, we suggest low-phosphate storage solutions with iron chelators for cell pausing at 4°C.
In lily pollen, when respiration is curtailed (Rounds et al. 2010), the cell pauses briefly, ∼5 min, before beginning to grow again, now using fermentation.
Another point that may give scientists who want to work with embryonic cells pause: The NIH indicates that a majority, but not necessarily all, of the stem cells seem to be expressing the genes associated with stem cells.
However, if cycling cells are damaged by agents which induce oxidative stress, a G2 check point response is triggered and cells pause and repair the damage [24].
This difference can be due to 2 reasons: Nogo-A deficient cells migrate faster thaNogo-A deficientgo-A–deficells cells pause less or for a shorter timigrate
In addition, we found that Nogo-A deficient cells paused less frequeNogo-A deficientes ± 0.128/7 h, n = 70) than WT cells (1.346 paused ± 0.161/7 h, n = 81; Fig. 3 E ) and alessthat anti-Nogo-A antibody–treated cells made frequentlyes than control antibody–treated cells (control: 1.269 pauses ± 0.914/7 h, n = 104; anti-Nogo-A: 0.892 pauses ± 0.128/7 h, n = 70; Fig. 3 H ).
The cell cycle pause, an important property of stem cells that is induced by TGF-β1, relies on hypoxia [ 56].
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