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Because normal and tumor stem cells often share common pathways, the use of drugs that target specific stem cell pathways is both a powerful strategy and a great challenge.
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Cell Pathways was a developer of cancer therapies in Horsham, Pa.
While many T cells pathways are linked to known immune/inflammatory networks, the majority of the top B cell pathways are linked to cell growth, survival and metabolism.
A cluster of genes showed a specific profile for tumors of malignant potential, for which the transcriptional factors involved in the primary anabolic and catabolic cell pathways were down-regulated (Cluster 2, 25 genes).
Similar dysregulation in the interferon response and myeloid cell pathways was seen possibly reflecting systemic changes.
Four pathways, most notably a human embryonic stem cell pathway, were over-represented among the CpG loci that were hypermethylated in YSTs.
Increased expression of the CC+ pathway yielded a significantly increased hazard rate while increased expression of EGFR and B-cell pathways was associated with a decreased hazard rate, holding other covariates constant.
Genes involved in the "FLT3 signaling in hematopoietic progenitor cells" pathway is also overexpresssed in CB-EPCs.
Therefore, components of the IL-17 and Treg cells pathway are considered highly "druggable" and are important targets for the treatment of these inflammatory and fibrotic diseases.
A similar pathway, the "CD28 receptor signaling in T helper cells" pathway was also downregulated in the jejunum, but substantial overlap between the two pathways suggested observation of the same events.
Additionally, how the TCA cycle interacts with other biochemical and cell signaling pathways is yet to be characterized.
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