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While the role of TP73L in squamous cell pathogenesis remains unclear, a recent study of SiRNA mediated TP73L inhibition in SCC resulted in reduced cell survival with maintenance of squamous characteristics [ 28].
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Although recent studies have begun to associate subsets of lncRNAs to specific regulatory mechanisms [ 27- 31], the relevance of their role in controlling normal cell physiology and pathogenesis remains unclear.
The role of γδT cells in asthma pathogenesis remains unclear.
It has been suggested that MERS may be caused by intra-myelinic axonal oedema or local inflammatory cell infiltration; however, the pathogenesis remains incompletely understood.
However, specific in vivo data relating to mechanisms by which mast cells may influence IBD pathogenesis remains limited.
The precise impact of the double-negative T-cell population for SIV transmission and pathogenesis remains to be determined.
However, accumulating evidence suggests that this virus can also affect other cell types resulting in diverse clinical manifestations, of which the pathogenesis remains to be fully elucidated.
However, accumulating evidence suggests that this virus can also infect other cell types resulting in diverse clinical manifestations, of which the pathogenesis remains to be fully elucidated.
Although a 75 85-kDa 75 85-kDa Cav2.1l fragment (CTF) is toxic in cultured cells, its existence in human brains and its role in SCA6 pathogenesis remains unknown.
Programmed cell death mechanisms may contribute significantly to lung cell death and tissue injury following exposure to cigarette smoke, though their role in COPD pathogenesis remains unclear [11].
The mechanism of CD13 in cGVHD pathogenesis remains unclear but may involve mediation of inflammatory responses by T cells.
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CEO of Professional Science Editing for Scientists @ prosciediting.com