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Studies have also suggested that BPA interferes with germ cell nest breakdown in animal models.
The numbers of CD56+ and GrB+ cells were counted exclusively within the primary tumor cancer cell nest.
Preliminary termination of either new oocyte or granulosa cell nest formation results in premature ovarian failure [ 85].
Combined with the effects on germ cell nest breakdown, there is strong evidence that BPA induces ovotoxicity by acting on developing and immature follicle stages in animals models.
After three gefitinib exposures, gefitinib-resistant cell line (UMSCC81B-GR3) was established in which a small number of variant cells with fibroblastic morphology appeared around epithelial cell nest.
In vitro analysis showed that a small number of fibroblastoid variant tumour cells appeared around the epithelial cell nest of UMSCC81B-GR3 cells.
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Deschoolmeester et al. showed that a high infiltrating CD3- and CD8-positive cells in cancer cell nests was correlated to improved overall survival in colorectal cancer [8].
While the underlying mechanism is unclear, the proliferating adult intestinal epithelial cells can be easily identified as multi-cell islets or cell nests around stage 60 [5], [5].
Histopathologic examination of control tumors revealed a network of dilated, anastomosing vascular spaces that formed between tumor cell nests and were filled with extravasated RBCs.
Minor salivary glands at the base of the tongue showed an immature architecture, characterized by branching solid cell nests and tubuli dispersed in abundant loose mesenchyma.
The extracellular matrix macromolecule tenascin was detected in the tumor graft as an extensive interstitial network entrapping cell nests of variable size.
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CEO of Professional Science Editing for Scientists @ prosciediting.com