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Multicellular organisms are generated by coordinated cell movements during morphogenesis.
Shimizu, T. et al. E-cadherin is required for gastrulation cell movements in zebrafish.
Hargreaves, D. C. et al. A coordinated change in chemokine responsiveness guides plasma cell movements.
Solnica-Krezel, L. Conserved patterns of cell movements during vertebrate gastrulation.
Warga, R. M. & Kimmel, C. B. Cell movements during epiboly and gastrulation in zebrafish.
Embryonic morphogenesis takes place via a series of dramatic collective cell movements.
Moreover, cell movements are highly correlated and in phase with ECM deformations.
Several key players of cell movements, such as Src and FAK, are known to be directly or indirectly regulated by ROS7,62,63, implying that localized ROS production by mitochondria also has important roles in cell movements.
To characterize TVC migration in control and experimental conditions, we developed quantitative parameters describing cell movements in live embryos.
A typical movie can show the cell movements in a 170 x 140 x 200 μm volume during 30 minutes.
Military police soldiers noted in handwritten entries that the cell movements were part of interrogation plans and that they were carefully organized.
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