Sentence examples for cell life span from inspiring English sources
However, in certain types of cancer, telomere regulation of cell life span is rendered dysfunctional.
Gatto, D. et al. Regulation of memory antibody levels: the role of persisting antigen versus plasma cell life span.
Telomeric control of cell life span appears to be inactivated by the expression of oncogenes (cancer-causing genes) or by the deactivation of tumour suppressor genes.
He was an acknowledged expert in the mechanisms of red blood cell aging and the reduction of finite red cell life span in patients with cancer.
When telomeres have been reduced to a certain length, cell death occurs; thus, telomeres play an important role in determining cell life span.
Their subsequent studies revealed that telomerase plays a fundamental role in maintaining chromosomes because it can add DNA to telomeres, which shorten following cell division and are the primary determinants of cell life span.
These cutoff values were arbitrarily chosen; however, computational analysis of greater than 5000 individual mother cell life spans indicates that a wild type life span distribution will yield a 5-cell mean RLS of 15 or lower less than 0.3% of the time and 20 or lower approximately 7% of the time (Figure S1).
Antioxidant treatment downregulated the expression of p19Arf in Zfp277−/− MEFs and extended the cells' life span during culture ex vivo.
Furthermore, NAC treatment of wild-type and Zfp277−/− MEFs significantly repressed the expression of p16Ink4a and p19Arf (Figure 3C) and extended the cells' life span, although NAC itself had a mild adverse effect on proliferation as evident from the growth retardation of Zfp277−/− MEFs at early passages (Figure 3D).
Consistent with the above, increased mitochondrial respiration extends life span in yeast whereas in mammalian cells life span extension correlates with reduced respiration [ 37, 39, 43].
Lanza, R. P. et al. Extension of cell life-span and telomere length in animals cloned from senescent somatic cells.
