The occurrence of misfolded p53 proteins can lead to aggregation and subsequent ubiquitination in the cell, leading to p53 inactivation [648], [649].
As illustrated in Fig. 13, different VT lead to different initialization compliance current in the STI-RRAM cell, leading to further mismatch in RL,L.
Eukaryotic cells respond to hyperosmotic conditions by expunging water from the cell, leading to cell shrinkage.
The calcium poisons mitochondria — organelles that power the cell — leading to the release of even more free radicals.
Soon after, the viral genome begins to dictate events in the cell, leading to the production of many more virus particles, and full-blown infection gets under way.
Indeed, the internalization of ADCs precedes the release of the cytotoxic drug within the lysosomal compartment of the cell, leading to cell death and manifestation of tumor regression.
A barium chloride solution was then injected into the flow cell, leading to fast dissolution and replacement of celestite by barite (or baryte, BaSO4).
Furthermore, a number of cytotoxic chemotherapy agents, such as doxorubicin, 5-fluorouracil, and oxaliplatin, can induce either genomic or cytoplasmic stress in the tumour cell leading to immunogenic cell death (Zitvogel et al, 2008b).
Its unique action mechanism produces irreversible nanopores in the membrane of the cell leading to apoptosis; therefore irreversible electroporation can be used to ablate substantial volumes of tissue without the undesirable thermal effects as the "heat sink effect".
Assembly of human immunodeficiency virus type 1 is driven by oligomerization of the Gag polyprotein at the plasma membrane of an infected cell, leading to membrane envelopment and budding of an immature virus particle.
Series of gain-of-function missense mutations in PDR1 and PDR3 that encode transcription factors are known to increase the expression of ABC transporters that extrude various kinds of drugs out of a cell, leading to pleiotropic drug resistance (PDR).
