Chemotaxis of D. discoideum has so far mainly been described by means of optical microscopy providing data on cell shape changes and the velocity of migrating amoebae., However, changes in cell-cell and cell-substrate interactions associated with cAMP oscillations have so far not been addressed.
This triggers altered homotypic (cell-cell) and heterotypic (cell-ECM) interactions associated with altered expression of EMT/CSC-related genes, leading to enhanced cell growth and survival in the hypoxic environment, increased synthesis of ECM proteins, and increased ability of cells to migrate and invade the surrounding tissue.
These data suggest that the 3D micromass culture system represents an in vitro model of early chondrogenesis with dynamic cell signaling interactions associated with the mechanical properties of chondrocyte differentiation.
A model of an otherwise healthy cell with latent tuberculosis infection would then be represented as the interaction data available for the canonical cell, with the addition of interactions associated with the cell type describing the pathogen.
On the other hand, rich nodes are more likely to execute multiple functions under different cell types/conditions, and experimentally detected interactions associated to rich nodes are the union of these cell type/condition specific interactions, we can not deduce any interaction potential of those proteins connected to a rich node.
The study identified common molecular properties and network interactions associated with cell proliferation and death, and revealed associations with the immune response.
Enriched hits belong to protein interactions associated with cell cycle regulation, anti-apoptosis, and signal transduction.
Using genome-wide Chromatin Interaction Analysis with Paired-End-Tag sequencing (ChIA-PET), we mapped long-range chromatin interactions associated with RNA polymerase II in human cells and uncovered widespread promoter-centered intragenic, extragenic, and intergenic interactions.
Integrins are adhesion receptors that mediate cell cell as well as cell ECM interactions associated with tumor growth and angiogenesis in malignant gliomas (5, 23, 31, 39).
Changes in cell-extracellular matrix (ECM) and cell-cell interactions are associated with the progression of primary melanomas to malignancy.
