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We combined vaccination of a CD4 T cell inducer, rH4/CAF01, with a strong CD8 T cell inducer, Ad-H4.
We could identify the HNSCC microenvironment as a strong Th17 cell inducer.
The HMGB1 in situ acted as a stem cell inducer resulting in repair of damaged tissue/organ.
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At the immunological level, different parasites induce quite different responses characterised, for example, by protozoa that polarise responses towards Th1, whilst helminths are strong Th2 and regulatory T cell inducers.
After testing the bioactivity of bovine IL-10 on human monocytes, experiments with DCs were performed to test if bovine IL-10 is bioactive on other antigen presenting myeloid cells that are potent T helper cell inducers.
IL-17 is secreted by the Th17 subset of CD4+ lymphocytes, as well as CD8 T cells and innate cells, including natural killer T cells, lymphoid tissue inducer cells, innate lymphoid cells and γδ-T cells [ 10].
Nevertheless, it has been suggested that CD34-DC are more effective anti-tumor T-cell inducers than MoDC, both in vitro and in clinical DC vaccination studies [ 2, 14].
The enhanced clonogenicity stimulated by BCGV-Th2 cells was evidenced by an increase in the number and size of individual colonies, and the lower forward scatter of BCGV-Th2 cell-induced tumor cells on flow cytometry suggested their size was smaller than that of non-Th2 cells-inducer tumor cells.
There are several examples where zinc has behaved as apoptosis or programmed cell death inducer (Formigari et al. 2007; Wilson et al. 2007).
Bone marrow derived DCs from wild type or CD40−/− mice were matured with CpG then treated with the cell death inducer Vitamin D3 [17].
To allow flexible deployment in both dividing as well as non-dividing cell populations, inducer and reporter modules were incorporated in lentivirus vector particles.
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