Our results in mice did not demonstrate a selective down-regulation of T1 cell function based on the profile of cytokine production.
We have previously established a robust xenotransplantation model to study primary human AML biology and stem cell function based on the engraftment of primary AML samples into non-obese diabetic (NOD)/LtSz-severe combined immunodeficiency (SCID) IL2Rγcnull (NSG) mice.
In addition, we measured both the extent of regeneration after head and tail amputation (Table 1) and mitotic activity.> > The first category of molecules we expected to uncover was general regulators of stem cell function, based on the requirement for neoblasts in regeneration.
Genome-scale metabolic models have emerged as a valuable tool in the post-genomic era for illustrating whole-cell functions based on the complete network of biochemical reactions.
We assessed residual β-cell function based on both fasting- and arginine-stimulated C-peptide values.
Taken together, it is hard to draw a conclusion on the role of betatrophin in β-cell function based on currently available evidence.
54 Thirty weeks of exenatide use also resulted in improved β-cell function based on mathematical modeling of β cell in response to test meal in patients with T2DM who were treated with metformin and/or sulfonylurea.
Among those with ≥5 years of diabetes duration, 10.7% had preserved β-cell function based on the DCCT cutoff and 1.0% were above the 5th percentile of the NHANES population.
The improvements in glycemic control reported here were accompanied by a significant improvement in β-cell function based on HOMA-B, which is consistent with preclinical mechanistic findings with lixisenatide and other GLP-1 receptor agonists (8).
Secondary end points included changes in body weight, fasting plasma glucose (FPG), 7-point plasma glucose profiles (before each meal, 90 min after breakfast, lunch, and dinner, and at bedtime), and β-cell function based on fasting insulin, fasting C-peptide, fasting proinsulin-to-insulin ratio, and the homeostasis model assessment index of β-cell function (HOMA-B) (15).
