Sentence examples for cell engaging from inspiring English sources
We designed bispecific T cell engaging (BiTE®) antibody constructs specific for M2e by genetically fusing a single chain variable fragment (scFv) derived from an M2e-specific murine monoclonal antibody with a CD3ɛ-specific scFv.
By using an optical trap, a microparticle (e.g. cell, bead) can be manipulated non-destructively and directed towards a phagocytic cell, engaging cell surface receptors to trigger the phagocytosis process.
It was previously shown that toxic-metabolite stress is one of the most comprehensive and encompassing stress responses in the cell, engaging both the general stress (or heat-shock protein, HSP) response as well as specialized metabolic programs.
A complementary approach that does not require ex vivo manipulation of T cells involves the use of fusion proteins that combine tumor recognition and T cell engaging domains to redirect T cells to target tumors [ 14].
As a cell engages the surface it will bind to a finite number of integrins and apply an initial force at a few sites.
The cell engages different co-transcriptional mechanisms to maintain chromatin integrity over transcribed genes.
In that way, when a T cell engages the inhibitory molecule, it will transduce a positive signal instead of a negative signal and become activated.
Anti-Gal B cells engaging α-gal epitopes on transplated wild type mouse heart can be activated to produce their antibodies only if they receive help from T cells that are activated by allogeneic or xenogeneic peptides.
T-cell engaging bispecific antibodies (bsAbs) are a promising tool for cancer treatment.
T-cell engaging antibodies represent new therapeutic approaches for treating leukemia and lymphoma, with the bi-specific T-cell engaging (or BiTE®) antibody blinatumomab now being tested in pediatric leukemia patients, following encouraging results in adults [66].
ADA appearance was highly dynamic and potent which reflects the intrinsic immunogenicity of the T-cell engaging catumaxomab, that was probably enhanced by its repeated i.p. application [ 21].
