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What's driving T cell dysfunction?
Supplementary Figure 5 CD39 in TAMs drives T cell dysfunction.
Severe injury triggers antigen-specific T-helper cell dysfunction.
Two papers in Nature now identify NR4A transcription factors as key drivers of T cell dysfunction.
Crawford, A. et al. Molecular and transcriptional basis of CD4+ T cell dysfunction during chronic infection.
Jiang, P. et al. Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response.
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McCarty MF, Barroso-Aranda J, Contreras F. NADPH oxidase mediates glucolipotoxicity-induced beta cell dysfunction--clinical implications.
Vangoitsenhoven, R. et al. Foodborne cereulide causes beta-cell dysfunction and apoptosis.
Diabetes is a hyperglycemic condition characterized by pancreatic β-cell dysfunction and depletion.
Goh, T. T. et al. Lipid-induced beta-cell dysfunction in vivo in models of progressive beta-cell failure.
Shang, L. et al. beta-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome.
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