Sentence examples for cell driver from inspiring English sources
To test this hypothesis, we manipulated InR activity under the control of 386-Gal4, a pan-peptidergic cell driver (Taghert et al., 2001).
To find out whether sie is also required in the somatic FC for coordination of BC and FC migration, we used the RNAi lines in combination with the follicle cell driver GAL4 109–79 to knock down sie.
Rescue of PDFR expression with the Dv-E cell driver in this mutant background restores both morning and evening anticipation peaks, that is, these flies show an intact morning peak and more normal onset of evening peak activity (middle panel).
We next tested a follicle cell driver, T155-GAL4, whish is expressed early in the germarium in follicle cell precursors followed by expression in all follicle cells starting at stage 9 (Queenan et al. 1997; Liu and Montell 1999).
We confirmed that this is due to reduced sie activity by knocking down sie with RNAi in the follicle cells using the follicle cell driver P{GawB}109 79 and the two sie RNAi constructs.
Although the same experiment with the Dv-E cell driver (DvPdf-GAL4; Pdf-GAL80) failed to induce a phase-shift, the negative result probably reflects the requirement for dTrpA1 expression within PDF cells, which is inhibited by the presence of the Pdf-GAL80 transgene.
The discovery of epithelial stem-like cell drivers in cancer has revolutionized the search for the elusive Achilles heel in many neoplasms.
To selectively access M cells (PPK23-positive, PPK25-negative cells), we used a driver that labels both F and M cells (ppk23-LexA) while driving Gal80 with F cell drivers.
However, to distinguish genetic alterations which confer strong advantages to the tumor cell (drivers) from the more numerous neutral aberrations (passengers) is a difficult task.
It will be important to use Cap and Follicle cell drivers to confirm that the Wnt effects as stated are indeed specific to the ISC.
Our findings demonstrate that the IBC clinical phenotype is promoted by signaling from the microenvironment perhaps in addition to tumor cell drivers.
