Koning, D. et al. In vitro expansion of antigen-specific CD8+ T cells distorts the T-cell repertoire.
The approach could accurately distinguish samples from a person with malaria, which is characterized by the swelling of red blood cells, from samples from a person with sickle cell anemia, in which the red blood cells distort into a serrated crescent shape, the team reports today in the Biophysical Journal.
If the cell becomes distorted, the procedure is re-performed.
Furthermore, some cells expressing the m8 mutant show an abnormal morphology (Figure 3D): a large number of cells are distorted, and strings of connected budding cells (often three) are observed, indicating a possible link with a defect in the cytokinesis and/or cell polarity.
In 2 cases, dermal infiltrating cells were smaller, had less cytoplasm and were stained deeper than those in the epidermis; some cells had distorted and heterogeneous nuclei.
Epidermal infiltrated cells had distorted or cerebriform nuclei and perinuclear halo which were deeply stained.
But measurements of the size of the triangular subunits were made by flattening out the domed membrane of a dead and dried-out cell, which distorts the structure.
The current cold weather could slow down plants' spring growth because if the water inside them freezes, their cell walls distort.
Because of these spatial interactions, each cell is often distorted, and the core position of the cell is not always at its center.
Implementing a strictly random choice of division axis, which assumes no particular cell mechanism for division, leads to a significant relative distortion of the histogram bins for 5- and 6-sided cells, again distorting the previously very good agreement with experimental data (Figure 3a).
