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Studies using dispersed cells are subject to artifact distortions related to the quality of cell dispersal that determines the amount of cellular debris and aggregates, which affect the DNA histograms[ 9].
Within the tips of the branching ureteric epithelium, cells respond to mesenchyme-derived trophic factors by proliferation, migration, and mitosis-associated cell dispersal.
The success of these therapies will be dependent on the development of surgical techniques designed to ensure precise cell placement while minimizing surgical trauma, adverse tissue reaction and cell dispersal.
Therefore, in the present study we investigated whether a NO precursor, isosorbide mononitrate (ISMN) or its analogue D-isosorbide can induce bacteria cell dispersal from Staphylococcus aureus (S. aureus) biofilms and explored the potential synergy of ISMN and the antimicrobial compounds mupirocin and ciprofloxacin in biofilm eradication.
Mice null for Reelin show no Purkinje cell dispersal and are profoundly ataxic (reeler mutants: e.g., 22 24).
Previous studies have shown that the functional deletion of both Apoer2 and Vldlr is necessary to block all perinatal Purkinje cell dispersal and recapitulate the reeler phenotype [25].
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The xenografts metastasize to lungs and lymph nodes (LNs) [ 17], but the role of hormones, if any, in tumor-cell dispersal is unclear.
Also, our work and that of others [ 31] has shown that cell morphology is linked to dispersal and movement in this species: highly elongated cells (dispersal morphs) are capable of long distance dispersal due to growth of flagella [ 31], somewhat elongated cells are capable of short distance dispersal, and round cells are fairly sedentary (although not immobile; Figure 1).
Here we show that EphA receptors regulate prostate cancer cell dissemination in a 2D dispersal assay and in a 3D cancer cell spheroid assay.
The model simulates grasshopper dynamics within each cell and dispersal between adjacent cells at each time step from the completion of hatching to ovipositing.
If the distance was greater than zero, the target cell for dispersal was chosen randomly from all cells of the specified distance.
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