The process of invasion begins when one cancer cell detaches itself from the mass of tumour cells.
If a cell detached from the ECM due to the loss of polarity, it will activate the apoptosis pathway.
As a cell detached from one cell, it could form a contact with another cell, in which GFP-E-cadherin accumulated.
Real-time visualization of cell detachment in the dynamic regime shows that cells detach either cell-by-cell or by collectively (for which intact parts of the monolayer detach as cell sheets).
Seeded hMSCs attached to the material prior to enzymatic cleavage, but a significant population of the cells detach after cleavage and release of RGD.
In our previous study, reducing culture temperature below the lower critical solution temperature (LCST) of PIPAAm (32 °C), cells detach themselves from hydrated PIPAAm grafted surfaces spontaneously.
3– 5 During EMT, epithelial cells detach from neighboring cells and acquire an elongated, mesenchymal-like morphology.
In order to metastasize, tumor cells detach from the primary tumor and invade the surrounding tissue.
We found that when treated with trypsin, adherent cells detach and round with sigmoidal dynamics.
HEK cells detach upon starvation and the response of COS cells is complex (and needs to be investigated further).
