The major advantages of the induced endothelial-like cells described here are simple, fast and efficient.
Cultured cardiac explants produce a heterogeneous population of cells including a distinctive population of refractile cells described here as small round cardiac explant derived cells (EDCs).
Strikingly, the T-IhNSC cells described here, display a unique capacity to generate bona-fide oligodendrocytes, which rarely appear in differentiated parental cultures.
Conceivably, the autoregulatory properties of B-1 cells described here may play a role in healthy individuals in preventing excessive activation of self-reactive B cells via TLR stimulation.
Although the XEN-P cells described here show the molecular signature and differentiation potential known or expected from the committed extraembryonic endoderm precursor, their path of origin remains to be understood.
In addition, IgM+ cells described here barely co-express other surface isotypes.
We used mutational information from the genomes of the 37 micro-dissected cells described here to reconstruct their lineage tree.
The mechanism involved in the autoinduction of HRG in resistant cells described here differs from the transient activation of HRG previously reported in trastuzumab-treated cells [ 49].
Because the patient-derived differentiated cells described here recapitulate the genetic aspects of FRDA and express measurable phenotypes, these cells should facilitate research into FRDA pathogenesis and treatment.
