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F4/80 staining of liver sections confirmed the effectiveness of Kupffer cell depletion (Fig. 4a).
Mahevas, M. et al. B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells.
Dhirapong, A. et al. B cell depletion therapy exacerbates murine primary biliary cirrhosis.
While mast cell depletion had no effect, silencing Stat6 significantly reduced lethality.
He and his team demonstrated that B cell depletion therapy has sustained efficacy in MG.
Barr, T. A. et al. B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6-producing B cells.
Similar(25)
Transient T-cell depletion causes regression of melanoma metastases.
Hauser, S. L. et al. B-cell depletion with rituximab in relapsing-remitting multiple sclerosis.
Hauser, S.L. et al. B-cell depletion with rituximab in relapsing-remitting multiple sclerosis.
More recently, protocols have been developed that substitute a costimulatory blockade for some or all of this T-cell depletion.
(f) Effect of CD8+ T-cell depletion in WT and AHRLysM mice performed as previously described 52.
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