Sentence examples for cell degeneracy from inspiring English sources

Random complex mixtures of polypeptides such as glatiramer acetate (GA) were among the first to be applied as immunodulators that take into account T cell degeneracy.

Our results suggest that reactivity to hLFA1 peptide in peripheral blood may be the result of T cell degeneracy.

Our results suggest that reactivity to the hLFA1 peptide in peripheral blood may be the result of T cell degeneracy.

An additional, and in our opinion better explanation, is that reactivity to the hLFA1 peptide in peripheral blood is in large part the result of T cell degeneracy.

And their immediate disappearance in the later stages of infection in resistant genotype libraries and continued expression in susceptible genotypes supports a hypothesis that continual expression of this protein may lead to mitochondrial dysfunction and subsequent cell degeneracy.

Pathogen-specific memory T cells, by virtue of the inherent degeneracy of T-cell receptor recognition of peptide:major histocompatibility complex ligands, may exhibit cross reactivity with allogeneic peptide:major histocompatibility complexes and thereby mediate graft rejection.

However, in this essay we discuss an alternative aspect of degeneracy in T cell recognition: the notion that peptides can assume different "registers" in the groove of a single MHC molecule, as first suggested and demonstrated by Sercarz and co-workers (reviewed in [J. autoimmun. 16 (2001) 201]).

Also for each case, the calculated current-voltage characteristic per super-cell shows that the spin degeneracy in the system is obviously broken and the current becomes strongly spin dependent.

In particular, we discuss two new insights: degeneracy among CD8 T cells appears to be substantially less than among CD4 T cells, and T cell clones characterized by a high affinity TCR interaction with a given pMHC complex are less degenerate than lower avidity T cells that require higher levels of pMHC complex for their activation.

Limited success with antigen-specific immunotherapies has led to the identification of novel approaches which consider the degeneracy of the T cell response, i.e. their ability to respond to multiple antigenic peptides.

Based on results from this model, we hypothesize, due to the considerable degeneracy in the T cell repertoire, that induction of full-blown autoimmune disease via molecular mimicry is a tightly regulated process requiring multiple factors related to the pathogen expressing the potential mimic epitope.